David's Daily Bread
News and Scripture each morning. Practical tools each evening. Loved by God.

Scripture accompanies each story for the reader's reflection. It is not presented as God's judgment on the people or events reported.

Lead story
Technology

Google DeepMind publishes a predictive map of all 9 billion single-letter DNA changes in the human genome

A petabyte of predictions, free to browse, and explicitly not a diagnosis.

Google DeepMind released AlphaGenome Atlas on Tuesday, a one-petabyte dataset of predicted molecular effects for all 9 billion possible single-letter changes to human DNA, which the lab says is more than 30 times larger than its AlphaFold Database. Each variant carries thousands of gene-regulation predictions across hundreds of human and mouse cell types and tissues, plus a single Variant Impact score that combines AlphaGenome and AlphaMissense outputs. Collaborators who contributed scientific input include the Stowers Institute for Medical Research, the Broad Institute, the University of Exeter, Memorial Sloan Kettering Cancer Center and Boston Children's Hospital. Access is free for non-commercial research through the website now, with commercial access on Google Cloud promised later; DeepMind states the resource is not approved for any clinical use and is not a substitute for medical advice.

Scripture for Reflection

“Great are the works of the LORD; they are pondered by all who delight in them.”

We can slow down and ponder the intricacy of a body we did not design.

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Letters to the King
Is there a way to want something badly and still hold it loosely, or must a person choose?
From the Baker's own shelf

Beloved, you have described the whole art of a faithful life, and no, you need not choose. Wanting is not the enemy. I wanted the ark brought home to Jerusalem, and I danced before it with everything in me. I wanted to build the house of the LORD, and I gathered cedar and gold and iron for it as a man gathers for a wedding. Then the word came through Nathan that I would not build it, my son would; and I sat down before the LORD and blessed Him. I did not stop wanting. I stopped gripping. There is the difference. A closed fist and an open hand may hold the very same thing, but only one of them can receive anything else. So want your good thing with your whole heart. Work for it, pray for it, name it plainly, do not pretend to a coolness you do not feel. But every so often, set it down where God can see it, and ask yourself the honest question: if He says no, or not yet, or not by you, will I still bless Him in the morning? If the answer is yes, your hands are open, however tightly you are working. And if the answer is no, that is not a scolding, that is simply where the prayer should start today.

– David, son of Jesse
Letters answered in the voice of the biblical King David.
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